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KMID : 0603820100160030161
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Journal of Experimental & Biomedical Science
2010 Volume.16 No. 3 p.161 ~ p.167
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Pharmacetical Characteristics of Solvent Fractions Isolated from Glycyrrhiza uralensis
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Kim Jun-Ho
Oh Hae-Sook
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Abstract
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In this study, the biological activities of Glycyrrhiza uralensis were investigated, including antioxidative, fibrinolytic, thrombin inhibitory, and α-glucosidase inhibitory activity. The hot water extract of Glycyrrhiza uralensis was fractionated into hexane, CHCl3, ethyl acetate, butanol, and water fractions, and each of these fractions were assayed individually. The water fraction showed the highest extraction yield of 19.45% (w/w). Using the DPPH method, the free radical scavenging activity was to be the strongest in the CHCl3 fraction at 89.3%. Using the fibrin plate method, only the butanol fraction showed a substantial plasmin activity of 0.62 units/ml. In thrombin inhibitory activity tests, a 100-fold dilution of the ethyl acetate fraction showed the strongest activity of 46.9%. In the α-glucosidase inhibitory activity assay, a 100-fold dilution of the CHCl₃ fraction showed the strongest activity of 80.6%. In conclusion, the combined results of this study demonstrate that the extracts of Glycyrrhiza uralensis can be used as a material for the development of biofunctional foods for diabetics.
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KEYWORD
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Antioxidative activity, Fibrinolytic activity, α-Glucosidase inhibitory activity, Glycyrrhiza uralensis, Thrombin inhibitory activity
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